Sometimes people use the term business plan when they are referring to a project. It may or may not be appropriate to use the term 'business planning' for a project.
Disclaimer Race against time to develop new antibiotics The second part of a series of three news features on antimicrobial resistance looks at how the antibiotics pipeline is drying up while resistance to existing drugs is increasing. Bulletin of the World Health Organization ; Once the infection — caused by one of the bacteria most often resistant to antibiotics — had been diagnosed, doctors put him on five different antibiotics.
Scenarios such as this IDSA case study are increasingly being played out all over the world. But not all the thousands of patients that contract drug-resistant bacterial infections every year are as lucky as Brock.
And the problem looks set to get worse. While infectious agents are becoming more and more resistant to the medicines that are currently in use, not enough drugs are being developed to combat them.
Courtesy of Infectious Diseases Society of America Young Brock Wade spent a month in hospital fighting an antibiotic-resistant infection. Right now, we have reasonable antibiotics to treat MRSA. As resistance catches up with them, in the future we will have problems again.
Now we have to dig deeper, think harder and more cleverly. Antibiotics, in particular, have a poor return on investment because they are taken for a short period of time and cure their target disease.
Only five major pharmaceutical companies — albeit five of the biggest — GlaxoSmithKline, Novartis, AstraZeneca, Merck and Pfizer, still had active antibacterial discovery programmes inaccording to an article published in the journal Clinical Infectious Diseases in January Adding to the grim picture, a comprehensive study of antibiotic development, covering innovative, small firms, as well as pharma giants, found in that only 15 antibiotics of under development had a new mechanism of action with the potential to meet the challenge of multidrug resistance.
Most of those were in the early phases of development, according to the study entitled The bacterial challenge: But there is hope. Another example is that of researchers at GlaxoSmithKline who recently described a novel class of antibacterial agents that target type IIA topoisomerases.
The article was published in Nature in August Antimicrobial resistance is the inevitable consequence of prescribing antibiotics. According to the study, every year at least 25 patients in the European Union alone die from an infection caused by multidrug-resistant bacteria and estimated additional health-care costs and productivity losses are at least 1.
Some of the most resistant infections are caused by Gram-negative Acinetobacter, and by certain strains of Klebsiella and Pseudomonas species, according to Spellberg. These bacteria cause a variety of illnesses ranging from hospital-acquired pneumonia, bloodstream infections, urinary tract infections from catheters, abdominal infections and even meningitis in people who have had head and spine procedures, for example, epidurals during labour.
The outbreak of resistant strains of Escherichia coli E. The solution may lie not only in scientific discovery but also in the economic incentives for developing drugs.
With the right set-up, pharma companies will have no incentive to drive use. Maybe they will not do any promotion at all.
Use would be agreed with public policy-makers, purchasers and national health systems. What is really needed is a collection of incentives that address the multiple obstacles to success.
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